The association between influenza vaccine in pregnancy and adverse neonatal outcomes.
Identifieur interne : 000402 ( Main/Exploration ); précédent : 000401; suivant : 000403The association between influenza vaccine in pregnancy and adverse neonatal outcomes.
Auteurs : Linda Dodds ; Noni Macdonald ; Jeffrey Scott ; Anne Spencer ; Victoria M. Allen ; Shelly McneilSource :
- Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC [ 1701-2163 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- effets indésirables : Vaccins antigrippaux.
- épidémiologie : Naissance prématurée.
- Adulte, Femelle, Grossesse, Humains, Issue de la grossesse, Nourrisson à faible poids de naissance, Nouveau-né, Nouvelle-Écosse, Odds ratio, Sous-type H1N1 du virus de la grippe A, Études de cohortes.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Influenza Vaccines.
- geographic : Nova Scotia.
- epidemiology : Premature Birth.
- Adult, Cohort Studies, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Influenza A Virus, H1N1 Subtype, Odds Ratio, Pregnancy, Pregnancy Outcome.
Abstract
OBJECTIVE
To determine whether neonatal outcomes differ between women vaccinated during pregnancy and those not vaccinated.
METHODS
Self-reported history of receipt of influenza vaccination during pregnancy was collected from women at the time of admission for obstetrical delivery at the IWK Health Centre in Halifax, Nova Scotia, beginning in April 2006. The cohort for this study included women who delivered a singleton infant prior to November 2009, reflecting the pre-pandemic H1N1 vaccination period. Neonatal outcomes were compared using logistic regression between vaccinated and non-vaccinated women.
RESULTS
Overall, 1957 of 9781 women (20%) included in the cohort received influenza vaccine during their pregnancy. The adjusted odds ratio and 95% confidence interval for a small for gestational age infant (lowest 10th percentile birth weight for gestational age and sex) was 0.80 (95% CI 0.65 to 0.95) for vaccinated women relative to non-vaccinated women. The adjusted odds ratio for a low birth weight infant was 0.74 (95% CI 0.58 to 0.95). Rates of preterm birth and a composite indicator of adverse neonatal outcomes were lower among vaccinated women, but were not statistically significant. The effects of maternal vaccination on neonatal outcomes did not differ between high- and low-risk women.
CONCLUSION
As evidence continues to mount in support of improved neonatal outcomes associated with receiving influenza vaccination during pregnancy, enhanced public health measures are necessary to encourage pregnant women to receive the influenza vaccine.
DOI: 10.1016/S1701-2163(16)35336-1
PubMed: 22947404
Affiliations:
Links toward previous steps (curation, corpus...)
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Allen</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, Halifax NS; Department of Obstetrics and Gynaecology, Dalhousie University, Halifax NS.</nlm:affiliation><wicri:noCountry code="subField">Halifax NS</wicri:noCountry></affiliation></author><author><name sortKey="Mcneil, Shelly" sort="Mcneil, Shelly" uniqKey="Mcneil S" first="Shelly" last="Mcneil">Shelly Mcneil</name><affiliation><nlm:affiliation>Canadian Center for Vaccinology, Halifax NS; Department of Pediatrics, Dalhousie University, Halifax NS; Department of Medicine, Dalhousie University, Halifax NS.</nlm:affiliation><wicri:noCountry code="subField">Halifax NS</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC</title><idno type="ISSN">1701-2163</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Infant, Low Birth Weight</term><term>Infant, Newborn</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza Vaccines (adverse effects)</term><term>Nova Scotia</term><term>Odds Ratio</term><term>Pregnancy</term><term>Pregnancy Outcome</term><term>Premature Birth (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Issue de la grossesse</term><term>Naissance prématurée (épidémiologie)</term><term>Nourrisson à faible poids de naissance</term><term>Nouveau-né</term><term>Nouvelle-Écosse</term><term>Odds ratio</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Vaccins antigrippaux (effets indésirables)</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Nova Scotia</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Premature Birth</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Naissance prématurée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Infant, Low Birth Weight</term><term>Infant, Newborn</term><term>Influenza A Virus, H1N1 Subtype</term><term>Odds Ratio</term><term>Pregnancy</term><term>Pregnancy Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Issue de la grossesse</term><term>Nourrisson à faible poids de naissance</term><term>Nouveau-né</term><term>Nouvelle-Écosse</term><term>Odds ratio</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To determine whether neonatal outcomes differ between women vaccinated during pregnancy and those not vaccinated.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Self-reported history of receipt of influenza vaccination during pregnancy was collected from women at the time of admission for obstetrical delivery at the IWK Health Centre in Halifax, Nova Scotia, beginning in April 2006. The cohort for this study included women who delivered a singleton infant prior to November 2009, reflecting the pre-pandemic H1N1 vaccination period. Neonatal outcomes were compared using logistic regression between vaccinated and non-vaccinated women.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Overall, 1957 of 9781 women (20%) included in the cohort received influenza vaccine during their pregnancy. The adjusted odds ratio and 95% confidence interval for a small for gestational age infant (lowest 10th percentile birth weight for gestational age and sex) was 0.80 (95% CI 0.65 to 0.95) for vaccinated women relative to non-vaccinated women. The adjusted odds ratio for a low birth weight infant was 0.74 (95% CI 0.58 to 0.95). Rates of preterm birth and a composite indicator of adverse neonatal outcomes were lower among vaccinated women, but were not statistically significant. The effects of maternal vaccination on neonatal outcomes did not differ between high- and low-risk women.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>As evidence continues to mount in support of improved neonatal outcomes associated with receiving influenza vaccination during pregnancy, enhanced public health measures are necessary to encourage pregnant women to receive the influenza vaccine.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22947404</PMID><DateCompleted><Year>2014</Year><Month>09</Month><Day>18</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1701-2163</ISSN><JournalIssue CitedMedium="Print"><Volume>34</Volume><Issue>8</Issue><PubDate><Year>2012</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC</Title><ISOAbbreviation>J Obstet Gynaecol Can</ISOAbbreviation></Journal><ArticleTitle>The association between influenza vaccine in pregnancy and adverse neonatal outcomes.</ArticleTitle><Pagination><MedlinePgn>714-720</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1701-2163(16)35336-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S1701-2163(16)35336-1</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine whether neonatal outcomes differ between women vaccinated during pregnancy and those not vaccinated.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Self-reported history of receipt of influenza vaccination during pregnancy was collected from women at the time of admission for obstetrical delivery at the IWK Health Centre in Halifax, Nova Scotia, beginning in April 2006. The cohort for this study included women who delivered a singleton infant prior to November 2009, reflecting the pre-pandemic H1N1 vaccination period. Neonatal outcomes were compared using logistic regression between vaccinated and non-vaccinated women.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Overall, 1957 of 9781 women (20%) included in the cohort received influenza vaccine during their pregnancy. The adjusted odds ratio and 95% confidence interval for a small for gestational age infant (lowest 10th percentile birth weight for gestational age and sex) was 0.80 (95% CI 0.65 to 0.95) for vaccinated women relative to non-vaccinated women. The adjusted odds ratio for a low birth weight infant was 0.74 (95% CI 0.58 to 0.95). Rates of preterm birth and a composite indicator of adverse neonatal outcomes were lower among vaccinated women, but were not statistically significant. The effects of maternal vaccination on neonatal outcomes did not differ between high- and low-risk women.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">As evidence continues to mount in support of improved neonatal outcomes associated with receiving influenza vaccination during pregnancy, enhanced public health measures are necessary to encourage pregnant women to receive the influenza vaccine.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dodds</LastName><ForeName>Linda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, Halifax NS; Department of Obstetrics and Gynaecology, Dalhousie University, Halifax NS; Perinatal Epidemiology Research Unit, IWK Health Centre, Halifax NS; Department of Pediatrics, Dalhousie University, Halifax NS.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>MacDonald</LastName><ForeName>Noni</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, Halifax NS; Department of Pediatrics, Dalhousie University, Halifax NS.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>Jeffrey</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, Halifax NS; Department of Pediatrics, Dalhousie University, Halifax NS.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spencer</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Perinatal Epidemiology Research Unit, IWK Health Centre, Halifax NS.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allen</LastName><ForeName>Victoria M</ForeName><Initials>VM</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, Halifax NS; Department of Obstetrics and Gynaecology, Dalhousie University, Halifax NS.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McNeil</LastName><ForeName>Shelly</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, Halifax NS; Department of Pediatrics, Dalhousie University, Halifax NS; Department of Medicine, Dalhousie University, Halifax NS.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Obstet Gynaecol Can</MedlineTA><NlmUniqueID>101126664</NlmUniqueID><ISSNLinking>1701-2163</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007230" MajorTopicYN="N">Infant, Low Birth Weight</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009674" MajorTopicYN="N" Type="Geographic">Nova Scotia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011256" MajorTopicYN="Y">Pregnancy Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D047928" MajorTopicYN="N">Premature Birth</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>9</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>9</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>9</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22947404</ArticleId><ArticleId IdType="pii">S1701-2163(16)35336-1</ArticleId><ArticleId IdType="doi">10.1016/S1701-2163(16)35336-1</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Allen, Victoria M" sort="Allen, Victoria M" uniqKey="Allen V" first="Victoria M" last="Allen">Victoria M. Allen</name><name sortKey="Dodds, Linda" sort="Dodds, Linda" uniqKey="Dodds L" first="Linda" last="Dodds">Linda Dodds</name><name sortKey="Macdonald, Noni" sort="Macdonald, Noni" uniqKey="Macdonald N" first="Noni" last="Macdonald">Noni Macdonald</name><name sortKey="Mcneil, Shelly" sort="Mcneil, Shelly" uniqKey="Mcneil S" first="Shelly" last="Mcneil">Shelly Mcneil</name><name sortKey="Scott, Jeffrey" sort="Scott, Jeffrey" uniqKey="Scott J" first="Jeffrey" last="Scott">Jeffrey Scott</name><name sortKey="Spencer, Anne" sort="Spencer, Anne" uniqKey="Spencer A" first="Anne" last="Spencer">Anne Spencer</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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